Who we are

IXTAL is a research-driven company that provides solutions in the field of protein science, structural biology and drug design.

IXTAL offers discovery services for the production and purification of target proteins, their biochemical and biophysical characterisation, and their X-ray structural analysis.

IXTAL services and expertise include in silico drug design, lead optimisation and small molecule X-ray diffraction for single crystal structure determination.


Team


Davide Ferraris

Crystallography

Riccardo Miggiano

Enzymology

Alberto Massarotti

Drug design

Prof. Menico Rizzi

Scientific Advisor

Last News


April 2018

Our last paper accepted in Biochemical and Biophysical Research Communications journal. For more info: click here

November 2017

IXTAL will attend the "Circular Bioeconomy Arena Meeting" that will take place on November 22, 2017 in Milan (Italy). For more info: click here

August 2017

IXTAL has been invited to present at the “Industrial and Molecular Biotechnologies” session of the 59th Congress of the Italian Society of Biochemistry and Molecular Biology (SIB), that will take place from the 20th to 22nd of September 2017 in Caserta (Italy). For more info: www.sib2017.it

July 2017

IXTAL publishes, in collaboration with Almirall and NovaRes, a research paper detailing the molecular structures of isomers of the immunostimulatory molecule Pidotimod® (link)

12 March 2017

IXTAL will attend the partnering event of the 5th International Conference on Bio-Sensing Technology - 7 – 10 May 2017 – Riva del Garda, Italy (www.b2match.eu/biosensing2017)

Our Services


Cloning, Expression and Purification of Proteins

Cloning strategies

Heterologous expression of proteins

Recombinant protein production

Protein chromatography purification

Protein Analysis

Biochemical and biophysical characterisation

Electrophoretic analysis

Protein-protein and protein-ligand interaction studies

X-ray Crystallography

Robot-assisted crystallization screening

X-ray data collection and analysis

Structural studies

Drug Design

Molecular docking simulation

Molecular dynamics simulation

Ligand design

Protein Engineering

Random mutagenesis

Site-directed mutagenesis

Chimeric proteins

Research

Rossi, F. et al. Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with a fluorescent probe Biochemical and Biophysical Research Communications. Just accepted.

Sarno, S. et al. Absolute structure and structure-function relationships of 4R,2′R and 4S,2′S Pidotimod® Journal of Molecular Structure. Volume 1147, 5 November 2017, Pages 810-814. View at Publisher


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Get in touch


Google Map of via bovio 6, novara, it
Main Office
IXTAL srl
via Bovio 6
28100 Novara (Italy)
 
Phone: (+39) 0321.375.715
Fax: (+39) 0321.375.821
P.I. 02426370033
Email
info@ixtal.it
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